منابع مشابه
Neuregulin 1 genotype and schizophrenia.
The neuregulin 1 (NRG1) gene has been the subject of considerable excitement within the psychiatric genetics literature since it was originally identified as a potential susceptibility locus for schizophrenia. Here we provide an update of our first meta-analysis of this association. Case-control and family-based genetic association studies of the NRG1 gene in healthy control groups and clinical...
متن کاملNeuregulin 1 and susceptibility to schizophrenia.
The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems. Here, we repor...
متن کاملAntipsychotic treatment and neuregulin 1-ErbB4 signalling in schizophrenia.
Evidence from genetic, transgenic and post-mortem studies has strongly supported the critical role that neuregulin 1 (NRG1) and its ErbB4 receptor plays in the pathophysiology of schizophrenia. This article aims to review current evidence regarding the effects of antipsychotic treatment on NRG1-ErbB4 signalling. NRG1 and ErbB4 knockout mice display abnormal behaviours relevant to certain featur...
متن کاملisrupted in Schizophrenia 1 Genotype and Positive ymptoms in Schizophrenia
ackground: Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizohrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and unction of the hippocampus. Because positive symptoms in SZ have also been associated with hippocampal structure and function, we ypothesize...
متن کاملBACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia
Schizophrenia is a chronic psychiatric disorder with a lifetime prevalence of about 1% in the general population. Recent studies have shown that Neuregulin-1 (Nrg1) is a candidate gene for schizophrenia. At least 15 alternative splicing of NRG1 isoforms all contain an extracellular epidermal growth factor (EGF)-like domain, which is sufficient for Nrg1 biological activity including the formatio...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2007
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbm129